Phase I/II clinical trial - Pédiatrie Tumeurs cérébrales

NIVOGLIO
Pédiatrie Tumeurs cérébrales
Ouvert depuis le: 09.17.2021
Site: Paris
Public cible
Enfant
Phase I-II study of nivolumab in combination;with temozolomide and radiotherapy;in children and adolescents;with newly diagnosed high-grade glioma
Description de l'essai

Study evaluating 1) feasibility (number of DLT) , 2) efficacy (EFS at 1 year) of a treatment combining standard (irradiation and temozolomide) immunotherapy by Nivolumab in children and adolescents just operated on for high-grade gliomas supratentoriels (outside the middle line and mutated H3K27)