Bioinformatics engineer (M/F)

Date de clôture
Lieu(x) de travail
Orsay
Secteur
Centre de Recherche
CDD
The Institut Curie Research Center
Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital Group and a Research Center of more than 1000 employees with a strong international representativeness.
The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Job description

Laboratory

The team “RNA, Tumor Microenvironment and Metastasis”, led by Albertas Navickas, has been recently established at Institut Curie, in the “Genome Integrity, RNA and Cancer” (UMR3348) department in Orsay. We focus on the gene regulatory networks promoting the establishment of the metastatic niche. For this, we combine single cell genomics with the tissue modelling ex vivo using human stem cell-derived organoids. More information is accessible at https://institut-curie.org/team/navickas.

We are looking to hire a bioinformatics engineer to participate in various projects of the lab, under the direct supervision of the PI, and in collaboration with the Bioinformatics core of Institut Curie. The position will be based in Orsay, with regular meetings and trainings in Paris.

Missions

  • Analysis of single-cell RNA-seq data (10x platform), including custom applications (RNA velocity, ligand-receptor interactions, Perturb-seq, etc.)
  • Analysis of lineage tracing data, including at a single-cell resolution
  • Analysis of bulk RNA-seq data, and other sequencing-based approaches (3’-end RNA-seq, CLIP-seq, miCLIP-seq, DRIP-seq, etc.): differential gene expression, gene set enrichment analysis, peak calling, DNA/RNA motif analysis, etc.
  • Analysis of clinical data (TCGA and other databases, regression analysis, multivariate hazard models, etc.).

 

Candidate Profile

Training and experience required

  • Master or PhD degree in bioinformatics, computational biology, data science or related.

Skills required

  • Strong background in sequencing data analysis
  • Proficiency in Unix, R, Python
  • Basic understanding of molecular & cell biology
  • Independence in project management
  • Collaborative attitude.

 

All our opportunities are open to people with disabilities

 

Contract information

  • Type of contract: Fixed-term contract
  • Starting date: October 2022
  • Duration: 12 months, renewable for 18 months
  • Working time: full time – 39 hours per week
  • Remuneration: according to the current grids
  • Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance
  • Location of the position: Orsay
  • Reference: 2022-08-UMR3348-BIOINF01

 

Contact

Please send your CV, letter of motivation and 2 references, to Albertas Navickas (albertas.navickas@curie.fr).

 

Publication date: August 2022

Deadline for application: October 2022

 

Institut Curie is an inclusive, equal opportunity employer

and is dedicated to the highest standards of research integrity.

Exemple : +33112365489
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