MICHAEL HENDERSON

Doctor
Recherche - Paris
Spécialités / domaines
Physics of living systems,
Multi-scale physics-chemistry-biology and cancer (molecules, cells, tissues and organisms)
Functions within Institut Curie:
Présentation

I received my PhD in Physical Chemistry from the University of Chicago (USA) where I studied how membrane-dependent mechanisms (e.g., membrane composition, membrane fluidity/rigidity, bilayer hydrophobic thickness, and lipid spontaneous curvature) alters antimicrobial peptide membrane selectivity and disruption. Currently, I am a shared postdoctoral researcher between the Bassereau team and the team of Chiara Zurzolo at Institut Pasteur. My research focus is to understand how membrane-deforming proteins from the Bin/Amphiphysin/Rvs (BAR) family (particularly IRSp53), and key actin-related processes in general, drive cellular protrusion formation, ranging from short sensory filopodia to long tunneling nanotubes (TNTs) that mediate cell-to-cell connectivity. In my project, I use a combination of surface micropatterning, live-cell imaging, and mechanical measurements using optical tweezers that allow me to apply my biophysical expertise to the cell biology of actin-based protrusions. 

Publications
A G316A Polymorphism in the Ornithine Decarboxylase Gene Promoter Modulates MYCN-Driven Childhood Neuroblastoma
Cancers
Laura D. Gamble, Stefania Purgato, Michelle J. Henderson, Simone Di Giacomo, Amanda J. Russell, Paolo Pigini, Jayne Murray, Emanuele Valli, Giorgio Milazzo, Federico M. Giorgi, Mark Cowley, Lesley J. Ashton, Jaydutt Bhalshankar, Gudrun Schleiermacher, Ali Rihani, Tom Van Maerken, Jo Vandesompele, Frank Speleman, Rogier Versteeg, Jan Koster, Angelika Eggert, Rosa Noguera, Raymond L. Stallings, Gian Paolo Tonini, Kwun Fong, Zalman Vaksman, Sharon J. Diskin, John M. Maris, Wendy B. London, Glenn M. Marshall, David S. Ziegler, Michael D. Hogarty, Giovanni Perini, Murray D. Norris, Michelle Haber