Research Director CNRS
Recherche - Paris
Spécialités / domaines
Cell biology,
Integrative tumor biology, immunology and environment,
Functions within Institut Curie:

Sebastian Amigorena obtained his PhD in Paris in 1990. After a 3 years post doc at Yale University, he returned to Paris in 1995 and started an Inserm AVENIR group together with Christian Bonnerot. Today, he is the head of the Immunology Department (INSERM U932, “Cancer Immunity”) at the Curie Institute. Sebastian Amigorena’s main scientific interest overlaps immunology and cell biology. In his graduate and post-doctoral studies, he analyzed the functions of IgG receptors and described the molecular basis of their inhibitory properties. Sebastian Amigorena is today an expert in antigen presentation and cross presentation in dendritic cells. He analyzed dendritic cells’ endocytic and phagocytic pathways and described several unique specializations of both pathways. Sebastian Amigorena and his team also made significant contributions to the analysis of cytotoxic T cells dynamics in vivo, during the initiation of immune responses in lymph nodes and during the invasion and rejection of solid tumors. More recently, he has contributed to understanding the epigenetic programing of T cell memory. Today, the team studies transposable elements, the regulation of their expression and their roles in anti-tumor immunity.

CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas
Nature Communications
Leticia Laura Niborski, Paul Gueguen, Mengliang Ye, Allan Thiolat, Rodrigo Nalio Ramos, Pamela Caudana, Jordan Denizeau, Ludovic Colombeau, Raphaël Rodriguez, Christel Goudot, Jean-Michel Luccarini, Anne Soudé, Bruno Bournique, Pierre Broqua, Luigia Pace, Sylvain Baulande, Christine Sedlik, Jean-Pierre Quivy, Geneviève Almouzni, José L. Cohen, Elina Zueva, Joshua J. Waterfall, Sebastian Amigorena, Eliane Piaggio
Splicing Patterns in SF3B1-Mutated Uveal Melanoma Generate Shared Immunogenic Tumor-Specific Neoepitopes
Cancer Discovery
Jeremy Bigot, Ana I. Lalanne, Francesca Lucibello, Paul Gueguen, Alexandre Houy, Stephane Dayot, Olivier Ganier, Jules Gilet, Jimena Tosello, Fariba Nemati, Gaelle Pierron, Joshua J. Waterfall, Raymond Barnhill, Sophie Gardrat, Sophie Piperno-Neumann, Tatiana Popova, Vanessa Masson, Damarys Loew, Pascale Mariani, Nathalie Cassoux, Sebastian Amigorena, Manuel Rodrigues, Samar Alsafadi, Marc-Henri Stern, Olivier Lantz
Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients
Nature Communications
Nicolas Gonzalo Núñez, Jimena Tosello Boari, Rodrigo Nalio Ramos, Wilfrid Richer, Nicolas Cagnard, Cyrill Dimitri Anderfuhren, Leticia Laura Niborski, Jeremy Bigot, Didier Meseure, Philippe De La Rochere, Maud Milder, Sophie Viel, Delphine Loirat, Louis Pérol, Anne Vincent-Salomon, Xavier Sastre-Garau, Becher Burkhard, Christine Sedlik, Olivier Lantz, Sebastian Amigorena, Eliane Piaggio