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Unit
FRANCK PEREZ / RENATA BASTO
Cell Biology and Cancer (UMR144)

The mission of this unit is to understand the biogenesis of the cell compartments and the molecular mechanisms that govern normal cellular functions.

The main research themes of the unit include:

  • Transport pathways between compartments,
  • The dynamics of the actin- and microtubule-based cytoskeletons,
  • Three-dimensional structures of molecular motors,
  • Mechanisms of cell division and cell migration,
  • The mechanisms involved in establishing the polarity of epithelia and their differentiation,
  • Signalling pathways associated with tumour progression in several mouse models and human tumours,
  • Regulation of adhesive systems during morphogenesis and development.
Key figures
165
members in 2020
34
PhD students in 2020
82
publications in 2020
Key publications
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News
  • Fluidité des chromosomes
    Manipulating chromosomes in living cells reveals that they are fluid
    For the first time, scientists from CNRS, Institut Curie and Sorbonne Université have been able to act physically on chromosomes in living cells. By subjecting the chromosomes to different forces using magnets, they discovered that chromosomes are in fact very fluid – almost liquid – outside cell division phases. This study is published in Science on July 29, 2022.
    01/08/2022
  • Image issue des microscopes du Nikon Imaging Center @Institut Curie-CNRS
    Nikon Imaging Center @Institut Curie-CNRS : une plateforme d’imagerie scientifique unique en France
    L’Institut Curie, le CNRS et Nikon annoncent le renouvellement de leur partenariat autour de leur plateforme d’imagerie scientifique de pointe : le Nikon Imaging Center @Institut Curie-CNRS. Unique centre d’imagerie scientifique de cette envergure en France, la plateforme célèbre, en 2022, ses 15 ans au service de la recherche fondamentale, biomédicale, et de l’innovation dans le domaine de la microscopie optique.
    13/05/2022
  • COMPRENDRE L’ARCHITECTURE ET L’ORGANISATION DES CENTROMÈRES
    UNDERSTAND THE ARCHITECTURE AND ORGANIZATION OF CENTROMERES
    Conducted at the Institut Curie, Daniele Fachinetti's team's work, Molecular Mechanisms of Chromosome Dynamics, represents a significant advance in our understanding of the basic architecture and molecular organization of human centromeres.
    22/03/2022
  • Michel Bornens
    Michel Bornens, a historic pillar of the Research Center
    A biologist specializing in the centrosome, co-founder in 1995 of the mixed research center dedicated to the cell and the cooperative Physics and Biology program at Institut Curie, Michel Bornens passed away on March 6, 2022, at the age of 84. Michel Bornens had been a long-term member of Institut Curie’s Board of Directors as staff representative.
    14/03/2022
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Scientific events
7 Jul
2022
Seminar Cell Biology Series
12h-23h
Nanoscopy powered by machine learning: Novel insight into subcellular structure
Fluorescence microscopy provides the ability to localize subcellular components and, uniquely, to study molecular dynamics in living cells. However, its application to subcellular structures, such as macromolecular complexes, membrane domains and organelles, has been restricted by the diffraction limit of visible light (~200-250 nm). Various super-resolution microscopy (nanoscopy) approaches have
5 Jul
2022
Seminar Cell Biology Series
11h-23h
Understanding the molecular mechanism of chromosome protection
Faithful chromosome segregation following complete DNA replication is crucial to preserve genome integrity. To achieve equal chromosome segregation, cells need to align condensed chromosomes to the metaphase plate (a process of so-called chromosome biorientation). This requires physical attachment of spindle microtubules (MTs) to the centromeres of sister chromatids through kinetochores (KTs).&nbs
31 May
2022
Seminar Cell Biology Series
11h-23h
Mechano-Immunology: Novel mechanical routes to drive inflammatory epigenomic programs
Nikhil Jain is a Birmingham Fellow working across the Institutes of Inflammation and Ageing, and the School of Chemical Engineering. Nikhil is a cell engineer who specializes in mechanobiology and developing novel bioengineering tools and techniques and combining them with cutting-edge epi-imaging, and advanced “omics” to tackle challenging questions in human h
22 Mar
2022
Seminar Cell Biology Series
11h-13h
Investigating cellular logistics with live-cell STED super-resolution microscopy
In the lab we use gene editing and live-cell super-resolution microscopy to study the mechanisms of membrane homeostasis in health and disease. To be able to image physiological molecular processes in the crowded cellular cytoplasm in living cells, we developed labelling methods for stimulated emission depletion (STED) super-resolution imaging in living cells and a pipeline for the rapid generatio
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